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Application of Organoselenium in Inhibiting Candida albicans Biofilm Adhesion


Now online in the Journal of Prosthodontics, an in vitro study co-authored by ACP members Stephan J. Haney, DDS, John P. Hanlon, DMD, MS, Konstantina Angelara, DDS, MSD, and Robert M. Taft, DDS that investigated the effect of incorporating organoselenium into 3D-printed denture base resin on C. albicans adhesion and biofilm formation.

Denture Stomatitis, a chronic mucosal inflammation associated with Candida albicans, is common among denture wearers. Differences in physical and chemical properties of denture base materials significantly affect microbial adhesion and biofilm development. Organic compounds, coating agents, and nanoparticle technologies are some of the strategies investigated to combat microbial adhesion.

Organoselenium-containing compounds have been reported to limit microbial colonization on medical devices such as membranes, lenses, and catheters; however, the possible anti-fungal capabilities of organoselenium compounds incorporated into 3D-printed denture base materials has not been investigated.

Thirty disks were fabricated using 3D-printed denture base resin and assigned to three experimental groups (10/group): disks without organoselenium (control), disks with 0.5% organoselenium (0.5%SE), and disks with 1% organoselenium (1%SE).

Microbial viability (CFU/mL) was quantified by the spread plate method, while Confocal laser scanning microscopy and scanning electron microscope were performed for quantifying the biofilm thickness and examining biofilm morphology.

Within the limitation of the study, the results suggest that the incorporation of organoselenium into 3D-printed denture base resin is effective in reducing C. albicans biofilm formation and growth on denture base material.

Alawadi, A, AbdulAzees, PA, Lin, C-Y, et al. Application of organoselenium in inhibiting Candida albicans biofilm adhesion on 3D printed denture base material. J Prosthodont. 2023; 1– 7. https://doi.org/10.1111/jopr.13733


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